Product Details
What is this medicine used for?
For the treatment of infections caused by susceptible organisms including lower respiratory tract infections, urinary tract infections, skin and soft tissue infections, septicemia, meningitis, gonorrhea, and bone and joint infections.
How much and how often should you use this medicine?
Cefuroxime is given by deep intramuscular injection, by slow IV
injection over 3 to 5 minutes or by intravenous infusion.
ADULT: Usual dose: 750 mg by IM or IV injection every 8 hours.
Severe infection: 1.5 g IV every 6 to 8 hours.
Pneumonia: 1.5 g IM or IV injection twice daily for 48 to 72 hours followed by oral cefuroxime therapy for 7 to 10 days
Acute exacerbations of chronic bronchitis: 750 mg IM or IV injection twice daily followed by oral cefuroxime therapy for 5 to 10 days.
Duration of both parenteral and oral therapy is determined by the
severity of the infection and the clinical status of the patient.
Meningitis: 3 g IV every 8 hours.
Gonorrhea: 1.5 g IM single dose, divided between 2 different
injection sites.
Surgical infection prophylaxis: Usual dose: 1.5 g IV before the
procedure; this may be supplemented by 750 mg IM every 8 hours for up to 24 to 48 hours depending upon the procedure.
INFANTS AND CHILDREN: 30 to 60 mg/kg daily, increase to 100
mg/kg daily if necessary, given in 3 or 4 divided doses.
NEONATES: May be given similar total daily doses but in 2 or 3
divided doses.
Meningitis:
Infants and Children: 200 to 400 mg/kg daily IV in 3 to 4 divided doses, decreased to 100 mg/kg daily after 3 days or when there is clinical improvement.
Neonates: 100 mg/kg IV daily, decreased to 50 mg/kg daily when indicated.
Impaired Renal Function:
Reduce dosage of cefuroxime in patients with markedly impaired renal function.
Adults with marked renal impairment: (creatinine clearance
10-20 mL/min) 750 mg twice daily is recommended and with severe impairment (creatinine clearance <10 mL/min) 750 mg once daily is adequate.
For patients on hemodialysis: 750 mg dose should be given IV or IM at the end of each dialysis. In addition to the parenteral use,
cefuroxime can be incorporated into the peritoneal dialysis fluid
(usually 250 mg for every 2 liters of dialysis fluid)
Or as prescribed by the physician.
Contraindications
Hypersensitivity to cefuroxime or to cephalosporin antibiotics
Warning and Precautions
Careful use in patients who have experienced an allergic reaction to penicillins or other beta-lactams. Renal function should be monitored in patients receiving high dose cephalosporins, the elderly, and those with pre-existing renal impairment.
Availability
RM Cefuroxime 750 mg vial Box by 1’s
